Rate of killing of HIV-infected T cells and disease progression.

نویسندگان

  • M A Huynen
  • A U Neumann
چکیده

H. Shuitemaker et al., J. Virol. 66,1354 (1992). X. Wei et al., Nature 373, 117 (1995). D. D. Ho et al., ibid., p. 123. S. A. Danner et al., N. Engl. J. Med. 333, 1528 (1995). M. Markowitz et al., ibid., p. 1534. J. J. Eron et al., ibid., p. 1662. J. V. Giorgi etal., J. Acq. Immun. Defic. Syndr. 6, 904 (1993). S. Rowland-Jones et al., Nat. Med. 1, 59 (1995). A. N. Phillips, Science 271, 497 (1996).

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Assessment of HTLV-I proviral load, HIV viral load and CD4 T cell count in infected subjects; with an emphasis on viral replication in co-infection

  Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV- I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated.   Materials and...

متن کامل

The Yin and Yang of ADCC-Mediating Antibodies

Antibodies mediating antibody-dependent cellular cytotoxicity et al., 2014) and that the CD4 mimetic sensitized infected cells to (ADCC) have been of increasing interest since their identification as a protective immune correlate in the RV144 clinical vaccine efficacy trial (Haynes et al., 2012). Earlier studies associated these non-neutralizing antibodies with protection against HIV infection ...

متن کامل

Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection

Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of co-infection HIV/HTLV-1 pathogenesis. This study compared clinical course and lab...

متن کامل

Prevalence of Occult Hepatitis B in HIV Positive Patients (Adolescents and Adults) in Kermanshah- Iran

Background Occult hepatitis B infection (OBI) is considered a risk factor for progression of liver disease in patients with hepatitis B virus (HBV) infection. This disease progression is reported to be more significant in those with concomitant HIV infection. We aimed to determine the prevalence rate of OBI in a sample of HIV-positive patients. Materials and Methods: Sixty-six HIV-infected pati...

متن کامل

Human Papillomavirus and Cancer - Immunological Consequences of MHC Class I Down-Regulation

Few studies have been conducted on the causative factors associated with the development of cancer. Infection by high risk human papillomaviruses (HPVs) have been implicated as causative agents in a variety of cancers. HPV is capable of evading immune system and establishing persistent infections. Prolonged infection and lesion maintenance are associated with higher risk of neoplastic progressi...

متن کامل

Inefficient Cytotoxic T Lymphocyte–Mediated Killing of HIV-1–Infected Cells In Vivo

Understanding the role of cytotoxic T lymphocytes (CTLs) in controlling HIV-1 infection is vital for vaccine design. However, it is difficult to assess the importance of CTLs in natural infection. Different human leukocyte antigen (HLA) class I alleles are associated with different rates of progression to AIDS, indicating that CTLs play a protective role. Yet virus clearance rates following ant...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Science

دوره 272 5270  شماره 

صفحات  -

تاریخ انتشار 1996